Rabies virus protection issues and therapy

Rabies virus protection issues and therapy

Rabies remains a serious and usually fatal disease in many countries. The World Health Organization (WHO) estimates that approximately 10 million people worldwide require medical treatment against rabies each year after being exposed to an animal suspected of having rabies. In the United States of America (USA), there are close to 40,000 post-exposure prophylaxis treatments administrated each y...

Protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene. 1984.

Inoculation of rabbits and mice with a vaccinia-rabies glycoprotein recombinant (V-RG) virus resulted in rapid induction of high concentrations of rabies virus-neutralizing antibodies and protection from severe intracerebral challenge with several strains of rabies virus. Protection from virus challenge also was achieved against the rabies-related Duvenhage virus but not against the Mokola viru...

A single immunization with recombinant rabies virus (ERAG3G) confers complete protection against rabies in mice

PURPOSE New alternative bait rabies vaccines applicable to pet dogs and wild animals are needed to eradicate rabies in Korea. In this study, recombinant rabies virus, ERAG3G strain was constructed using reverse genetic system and the safety, efficacy and immunogenicity of the ERAG3G strain was evaluated in mice and dogs. MATERIALS AND METHODS Using the full-length genome mutated amino acid at...

Rabies virus antinucleoprotein antibody protects against rabies virus challenge in vivo and inhibits rabies virus replication in vitro.

We previously reported that A/WySnJ mice vaccinated via a tail scratch with a recombinant raccoon poxvirus (RCN) expressing the rabies virus internal structural nucleoprotein (N) (RCN-N) were protected against a street rabies virus (D. L. Lodmell, J. W. Sumner, J.J. Esposito, W.J. Bellini, and L. C. Ewalt, J. Virol. 65:3400-3405, 1991). To improve our understanding of the mechanism(s) of this p...

Diagnosis of rabies and typing strains of rabies virus